Neoral is a prescription medicine given to help prevent transplant rejection in patients who have had a kidney, liver, or heart transplant. Transplant rejection happens when the body's immune system senses the new organ as "foreign" and attacks it.
Neoral has been used in combination with azathioprine and corticosteroids.
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Only doctors experienced in the management of systemic immunosuppressive medicines at doses used in solid organ transplantation and in the management of organ transplant patients should prescribe Neoral®.
Patients receiving Neoral® have an increased risk of infection that may lead to certain cancers. This increased risk of infection and the possibility of developing cancers may be related to how long and how much of these medicines are used in transplant patients. In kidney, liver, and heart transplant patients, Neoral® is given with other immunosuppressive medicines.
Neoral® Capsules MODIFIED and Oral Solution MODIFIED cannot be substituted with Sandimmune® (cyclosporine, USP) Capsules and Oral Solution without careful monitoring. For a given blood concentration, cyclosporine levels will be greater with Neoral® than with Sandimmune®. Cyclosporine blood concentrations should be monitored to avoid toxicity due to high concentrations.
Do NOT take Neoral® if you are allergic to cyclosporine or to any of the ingredients in Neoral®.
Neoral® may cause serious side effects, including:
Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Neoral® may affect the way other medicines work, and other medicines may affect how Neoral® works. Know the medicines you take. Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine.
The most common side effects are kidney problems (renal dysfunction), shaking of the body (tremor), excessive hair growth (hirsutism), high blood pressure (hypertension), and enlarged gums (gum hyperplasia).
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Neoral® (cyclosporine, USP) MODIFIED Capsules is a prescription medicine given to help prevent rejection in patients who have had a kidney, liver, or heart transplant. Neoral® has been used in combination with azathioprine and corticosteroids.
Please click here for full Prescribing Information, including Boxed WARNINGS.
Reference: 1. Neoral [prescribing information]. East Hanover, NJ: Novartis Pharmaceuticals Corp; 2015.